Abstract: Objective The clinical efficacy of the patients with ascending aortic aneurysm combined with aortic regurgitation before and after operation was analyzed by Bentall surgery. Methods From January 2014 to December 2018, 70 patients with ascending aortic aneurysm complicated with aortic valve insufficiency underwent Bentall operation in Cardiac Surgery Department of the First Affiliated Hospital of Bengbu Medical College were selected to observe the effect of operation and the grading of cardiac function before and after treatment, and to observe the differences of related ultrasound and serum indexes. Results All the 70 patients underwent successful operation, with an average cardiopulmonary bypass time (165.3±45.7) min, aortic occlusion time (98.3±26.4) min, perioperative mortality rate 4.29%, postoperative adverse reaction rate 25.71%, postoperative 93.75 The cardiac function of the patient was restored to grade Ⅰ-Ⅱ. Cardiac output (CO), stroke volume (SV) , left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) before and after Bentall surgery , amino terminal B-type natriuretic peptide precursor (NT-proBNP), cardiac fatty acid binding protein (H-FABP), galectin-3 (Galectin-3). The difference was statistically significant (all P<0.05). Conclusion Bentall operation is a safe and feasible method for the treatment of ascending aortic aneurysm and aortic valve insufficiency.