Abstract: Objective To observe the restoration of the nasolabial structure and symmetry of unilateral cleft lip before and 2 weeks after surgery, and to observe the improvement and development of the nasolabial morphology of the children after 1 year of follow-up. Compared with the previous research and measurement in our department, this study forms a systematic and integrated study, which provides a comparison and theoretical reference for the follow-up three-dimensional measurement research, and provides a detailed theoretical reference and clinical guidance for the repair of children with cleft lip. Methods A total of 35 children treated in our department from December 2015 to December 2017 were selected. The total width of the nose, the angular distance of the lip peak, the distance of the alar lip peak, the distance of the columella lip peak, the width of the nasal base, the width of the nostril, the height of the nostril, the length of the medial crest, the length of the medial column, and the height of the columella were measured by direct measurement method before and 2 weeks after surgery together with one-year follow-up to assess their nasolabial development. Results Paired t-test was performed on the 11 measurement items, and the results showed that P<0.05, indicating that there was statistical significance between the measurement items before and 2 weeks after surgery. Follow-up showed that most children with nasal labial form good improvement, the symmetry of the healthy side, double side lip high approximately equal to the area of scar is not obvious, the continuity of the lip bow and dry wet lips and form is good, no eclabium, bilateral nostrils, alar basal symmetry improve obviously, crest form of upper lip movement is not observed in children with depression and distortion. Conclusion After 1 year of follow-up and combined with the previous measurement studies in our department, the shape and fullness of the nasolabial, the continuity of the labial arch and the symmetry of the healthy and the affected sides of the unilateral cleft lip were significantly improved in the short term after repair. It can provide certain reference for the repair of children with cleft lip and the choice of the repair period of secondary deformity.