Abstract: Objective To investigate the clinical significance of prostatic arterial embolization(PAE) combined with laparoscopic radical prostatectomy for prostate cancer patients with large prostate glands(>80 g). Methods Sixteen prostate cancer patients with large prostate glands were treated during January 2014 to October 2018 in Jinhua Municipal Center Hospital. Sixteen cases (group A) which received laparoscopic radical prostatectomy 2 months after prostate biopsy by using B ultrasound guidance. In group A, there were 10 cases of T2b, 6 cases of T2c, aged from 65 to 79 years. Sixteen cases (group B) diagnosed with prostate cancer which received laparoscopic radical prostatectomy 2 months after prostatic arterial embolization. In group B, there were 9 cases of T2b, 7 cases of T2c, aged from 67 to 80 years. Operating time, amount of bleeding during operation, postoperative indwelling catheterization time, the hospital stay and complications were compared between group A and group B. Results All the 32 cases were operated successfully. Laparoscopic radical prostatectomy in large prostate glands poses a significant challenge to urologists. Two months after PAE, prostate volume decreased for 51.09%-38.45% in group B. In group B, operating time, amount of bleeding during operation, postoperative indwelling catheterization time, the hospital stay and complications were all better than those in group A (P<0.05). Moreover, the results of PSA of all 32 patients decreased to <0.01 ng/mL at postoperative two months. Conclusion For prostate cancer patients with large prostate glands which received laparoscopic radical prostatectomy 2 months after prostatic arterial embolization, it can reduce the difficulty of operation and reduce complications.