Abstract: Objective To analyze the effects of acupressure combined with Chinese traditional medicine for Tsusanli external application on motilin and gastrin in patients undergoing colorectal surgery, and to provide reference for the clinical treatment of patients undergoing colorectal surgery. Methods A total of 90 patients who underwent colorectal surgery in our hospital from June 2016 to March 2018 were selected, and the patients who received colorectal surgery from June 2016 to April 2017 were set as the control group (n=40), the patients who received colorectal surgery from May 2017 to March 2018 were set as the observation group (n=50). The control group was treated with routine treatment, while the observation group was treated with acupressure combined with Chinese traditional medicine for Tsusanli external, the recovery time of bowel sounds, the normal time of bowel sounds, the first exhaust time and the first defecation time after surgery were compared between the two groups; The gastric juice volume, the levels of motilin and gastrin before and after surgery and the incidence of postoperative incision infection, incision dehiscence, intestinal anastomotic fistula were compared between the two groups. Results The recovery time of bowel sounds, the normal time of bowel sounds, the first exhaust time and the first defecation time of the observation group were significantly earlier than those of the control group (all P<0.05); Before surgery there were no significant differences in gastric juice volume, the levels of motilin and gastrin between the two groups (all P>0.05), after surgery, the gastric juice volume of the two groups was significantly lower than that before surgery (all P<0.05), and the observation group was significantly lower than the control group (all P<0.05), the levels of motilin and gastrin of the observation group were significantly higher than those before surgery (P<0.05), and the observation group was significantly higher than the control group (all P<0.05); Overall complication rate of the observation group was significantly lower than that of the control group (P<0.05). Conclusion Acupressure combined with Chinese traditional medicine for Tsusanli external application can effectively improve the gastrointestinal function of patients after colorectal surgery, and it can reduce gastric juice volume, and improve the levels of postoperative motilin and gastrin, which has a certain safety.