Abstract: Objective General practice is a relatively new developing discipline in China. With the reform of the medical and health system, local governments and medical colleges attach more importance to the cultivation of general practitioners, and our school has listed Introduction to General Medicine as a compulsory course in medical education. Introduction to General Practice is a comprehensive medical discipline which is human-centered, community-oriented and family-oriented, integrates clinical medicine, preventive medicine, rehabilitation medicine and humanities and social disciplines. This paper combines case-centered, problem-based, community-oriented teaching mode (CPC) with traditional lecture-based learning (LBL). The application effect in the course of Introduction to General Practice is preliminary exploration, which provides beneficial reference for future teaching. Methods According to the digital table method, 248 students from the 2015 undergraduate clinical medicine majors of our school were randomly selected as the research subjects. They were divided into control group (n=120) and experimental group (n=128). The students in control group received the LBL method. On the basis of this, CPC and LBL teaching method were applied to the ones in experimental group. In the end, the teaching efficacy was evaluated according to the results of the general medical theory, test scores, questionnaires and teaching satisfaction. Results In the experimental group, the results of the general medical examinations and the appraisal scores of the students in the experimental group were significantly higher than those in the control group (all P<0.01). In addition, the evaluation of the general medical teaching in the questionnaire survey and teaching satisfaction in experimental group was superior to control group (P<0.01). Conclusion CPC combined with LBL teaching method is a scientific and effective teaching method that is suitable for Introduction to General Practice in medical colleges. It can enhance medical students' understanding of Introduction to General Practice, cultivate their comprehensive ability and knowledge application ability, and improve their post competence. It is worth popularizing in future teaching.