Abstract: Objective To investigate the influencing factors of the occurrence of thrombosis and blood flow infection in patients undergoing peripherally inserted central catheter (PICC). Methods A total of 1 008 patients with PICC in our hospital from January 2018 to August 2018 were selected as subjects. The clinical data, including general data, medical history, laboratory examination, were collected. Bivariate logistic regression analysis was used to screen the risk factors of thrombosis and related bloodstream infection. Results Thrombosis occurred in 45 out of 1 008 patients, the incidence was 4.46%. A total of 15 patients with PICC had bloodstream-related infections, the infection rate was 1.49%. Bivariate Logistic regression analysis showed that prolonged indwelling of PICC catheter was an independent risk factor for catheter-related bloodstream infection, puncture vein and FIB content were independent risk factors for thrombosis. Conclusion PICC patients have a high risk of thrombosis and complications of catheter-related bloodstream infections. Coagulation parameters and selection of puncture veins have a great impact on the occurrence of thrombosis. Long-term indwelling of PICC is an independent risk factor for catheter-related bloodstream infections. Therefore, on the one hand, nurses should strengthen the understanding of the complications of PICC patients with thrombosis and related hemorrhagic influenza infection, adopt targeted and predictable grading nursing intervention measures, and reduce the incidence of catheter-related thrombosis through drug prevention and grading nursing measures.