Abstract: Objective To study the effect of individualized continuous dietary nursing in patients with chronic hepatitis B and liver fibrosis. Methods A total of 196 patients with chronic hepatitis B and liver fibrosis who were treated in our hospital from January 2015 to January 2017 were selected as the subjects. Patients were divided into observation group and control group with random table method. After admission, both groups were given routine nursing education. Patients in the observation group were given individualized continuous dietary care interventions. The levels of serum total bilirubin (TBIL), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured before and 6 months after diet intervention. FibroScan was used to detect the degree of hepatic fibrosis. Quality of life scale (SF-36) was used to evaluate the quality of life of patients. Results There was no significant difference in TBIL, AST and ALT between the two groups (all P>0.05) before intervention. After intervention, the levels of TBIL, AST and ALT in the observation group were significantly lower than those in the control group (all P<0.05). There was no significant change in the control group. There was no significant difference in stiffness value between the two groups (P>0.05). After intervention, the levels of stiffness value in the observation group were significantly lower than those in the control group (P<0.05). There was no significant change in the control group. There was no significant difference in SF-36 value between the two groups (all P>0.05) before intervention. After intervention, the score of SF-36 in the observation group were significantly higher than those in the control group (all P<0.05). There was no significant change in the control group. Conclusion Continuous dietary care can help restore liver function and liver fibrosis of patients with chronic hepatitis B liver fibrosis, and can improve the quality of life of patients.