Abstract: Objective To evaluate the effect of continuous nursing on treatment compliance and quality of life of patients with chronic hepatitis B, and to provide scientific basis for reducing readmission rate and improving treatment. Methods From January 2016 to January 2017, 133 patients with chronic hepatitis B diagnosed in Shaoxing Municipal Hospital were randomly divided into observation group and control group. The control group was given routine nursing care. The observation group was given continuing nursing intervention. One year later, the patients' treatment compliance and quality of life were evaluated. Results The proportion of complete compliance, partial compliance and non-compliance in the control group was 58.73%, 28.57% and 12.70% respectively. The proportion of complete compliance, partial compliance and non-compliance in the observation group was 84.13%, 12.70% and 3.17% respectively. The compliance in the observation group was better than that in the control group (P<0.05). The first three lowest scores in the control group were health change, energy and physiological function in turn, in the observation group. The first three lowest scores were health change, physiological function and physical pain. There was no significant difference in the scores of physiological function, physical pain, general health status and physiological content between the control group and the observation group (all P>0.05), while the scores of physiological function, energy, social function, emotional function, mental health, health change and psychological content in the control group were lower than those in the observation group (all P<0.05). Conclusion Continuous nursing care for patients with chronic hepatitis B can improve their treatment compliance, make their treatment more standardized and achieve better long-term effect, which is of great significance to improve the quality of life.