茜芷胶囊联合妇科千金胶囊治疗IUD置入后阴道异常出血的临床观察

吴兰兰; 王芝英

doi:10.16766/j.cnki.issn.1674-4152.000890

茜芷胶囊联合妇科千金胶囊治疗IUD置入后阴道异常出血的临床观察

doi: 10.16766/j.cnki.issn.1674-4152.000890

吴兰兰^1, ,,
王芝英²

1. 象山县计划生育指导站, 浙江宁波 315700;
2. 象山县人民医院妇科, 浙江宁波 315700

基金项目:

国家卫计委重大疾病防治科技行动计划项目(ZX-01-C2015008)

详细信息

通讯作者:
吴兰兰,E-mail:1870219067@qq.com

中图分类号: R169.41;R711.73
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出版历程
- 收稿日期: 2018-11-28

Observe on the clinical effect of Qianzhi capsule combined with Gynecological Qianjin capsule on the treatment of abnormal vaginal bleeding after IUD implantation

WU Lan-lan^{1
, ,},
WANG Zhi-ying²

Family Planning Guidance Station of Xiangshan County, Ningbo, ZheJiang 315700, China

摘要

摘要: 目的观察茜芷胶囊联合妇科千金胶囊用于治疗IUD置入后阴道异常出血的临床疗效。方法以2016年2月—2018年2月象山县计划生育指导站收治的135例IUD置入后阴道异常出血患者为研究对象，按随机数字表法分为对照组、研究组1和研究组2，每组各45例。对照组不予以药物治疗，研究组1予以宫血宁胶囊口服治疗，研究组2予以茜芷胶囊联合妇科千金胶囊口服治疗。比较各组患者治疗前后血红蛋白和血清TNF-α、IL-6和IL-8含量，记录治疗期间药物不良反应，观察阴道异常出血改善和IUD因症取出情况。结果研究组2治疗后血清TNF-α、IL-6和IL-8含量均显著低于研究组1和对照组水平(均P<0.05)，血红蛋白含量显著高于研究组1和对照组水平(均P<0.05)，行经时间显著短于研究组1和对照组水平，月经出血量显著少于研究组1和对照组水平(均P<0.05)；研究组1和研究组2阴道异常出血改善率(100.00%和97.78%)均显著高于对照组水平(80.00%)，均P<0.05，且IUD因症取出率(0.00%和2.22%)均显著低于对照组水平(20.00%)，均P<0.05；各组药物不良反应总体发生率差异无统计学意义(P>0.05)。结论茜芷胶囊联合妇科千金胶囊可显著降低IUD置入后阴道异常出血患者炎症反应强度，提高血红蛋白含量，缩短症状改善周期，提高患者IUD续用率，且未增加药物不良反应发生率。
- 茜芷胶囊 /
- 妇科千金胶囊 /
- IUD置入 /
- 阴道异常出血 /
- 临床疗效
Abstract: Objective To observe on the clinical effect of Qianzhi capsule combined with Gynecological Qianjin capsule on the treatment of abnormal vaginal bleeding after IUD implantation. Methods A total of 135 patients with abnormal vaginal bleeding after IUD implantation were researched from February 2016 to February 2018. All the patients were divided into the control group(n=45), the study group 1(n=45) and the study group 2(n=45). The control group were not given medication. The study group 1 were given Gongxuening capsule orally. The study group 2 were given Qianzhi capsule and Gynecological Qianjin capsule orally. The levels of hemoglobin and serum TNF-α, IL-6 and IL-8 were compared between the different groups before and after treatment. The adverse drug reactions during treatment were recorded and the improvement of abnormal vaginal bleeding and the removal of IUD were observed. Results The serum levels of TNF-α, IL-6 and IL-8 in study group 2 were significantly lower than those in study group 1 and control group after treatment (P<0.05). The level of hemoglobin in study group 2 was significantly higher than those in study group 1 and control group after treatment (P<0.05). After treatment, the duration of menstruation was significantly shorter than those of study group 1 and control group, and the amount of menstrual bleeding was significantly less than those of study group 2 and control group (P<0.05). The improvement rates of abnormal vaginal bleeding (100.00% and 97.78%) in study group 1 and study group 2 were significantly higher than that in control group (80.00%), P<0.05, and the removal rate of IUD (0.00% and 2.22%) was significantly lower than that in control group (20.00%), P<0.05. There was no significant difference in the overall incidence of adverse drug reactions among the groups (P>0.05). Conclusion Qianzhi capsule combined with Gynecological Qianjin capsule can significantly reduce the intensity of inflammation in patients with abnormal vaginal bleeding after IUD implantation, increase the content of hemoglobin, shorten the improvement cycle of abnormal vaginal bleeding symptoms, improve the continuation rate of patients with IUD, and do not increase adverse drug reactions.
- Qianzhi capsule /
- Gynecological Qianjin capsule /
- IUD implantation /
- Abnormal vaginal bleeding /
- Clinical efficacy