Abstract: Objective To evaluate the application value and effect of chemical- mechanical detoxification in the treatment of rickets. Methods Firstly, the computer was used to search the digital journal full-text database, the Chinese journal full-text database and the Chinese biomedical literature database. Then the manual examination method was used to supplement the reference documents and conference papers attached to the computer. In this paper, the effect of chemical- mechanical decontamination technology in the treatment of rickets is mainly analyzed. The paper confirmed the application prospect of new chemical-machinery decontamination. The literature included in the study was evaluated using the Cochrane systematic review method and Meta-analysis was performed using RevMan 5.2. The evaluation indexes of chemical-mechanical decontamination include postoperative complications, time of decontamination, decontamination effect and degree of pain, and 1-year success rate. Results When compared chemical-mechanical decontamination and the conventional decontamination, the decontamination effect [OR=1.12, 95% CI: (0.71, 1.78), P=0.063], incidence of secondary sputum [OR=0.64, 95% CI: (0.36, 1.15), P=0.13], P>0.05, the difference was no statistical significance. The decontamination time [OR=2.77, 95% CI: (2.35, 3.18), P<0.05], incidence of pain [OR=0.13, 95% CI: (0.10, 0.16), P<0.05], incidence of pulp complications [OR=0.24 95% CI: (0.08, 0.72), P<0.05], the incidence of dental anxiety [OR=0.19, 95% CI: (0.12, 0.28), P<0.05], 1-year success rate [OR=1.81, 95% CI: (1.08, 3.04), P<0.05], the difference were all statistically significant. Conclusion As compared with conventional mechanical decontamination, chemical-mechanical decontamination has no significant difference in the treatment effect. Through the treatment time is increased, but it can reduce the incidence of pain, pulp complications and dental anxiety, and increase the success rate of one year.