Abstract: Objective To investigate the risk factors and nursing strategies for patients with colon cancer complicated with anemia. Methods A total of 198 patients with colon cancer who were admitted to our hospital from September 2016 to July 2018 were enrolled in the anemia group. One hundred and twenty-six patients with colon cancer who did not have anemia were anemia. The age, history of hypertension, history of diabetes, TNM stage, degree of pathological differentiation, vascular tumor thrombus, tumor diameter, tumor type, cancerous intestinal obstruction and hypoproteinemia of the two groups were counted, and single factor and Multivariate analysis identified risk factors for anemia in colon cancer patients. Results Univariate and multivariate logistic regression analysis showed that age, TNM stage, pathological differentiation, vascular tumor thrombus, tumor diameter, tumor type, cancerous intestinal obstruction and hypoproteinemia were associated with anemia in colon cancer patients. Conclusion Age, TNM stage, pathological differentiation, vascular tumor thrombus, tumor diameter, tumor type, cancerous intestinal obstruction and hypoproteinemia are risk factors for anemia in colon cancer patients. Risk factors should be emphasized in clinical practice. Good treatment and care to prevent the occurrence of anemia.