Abstract: Objective To investigate the application effects and the characters of seamless butt nursing in acute digestive endoscopy nursing, with a view to provide better basis and foundation for the application of seamless butt nursing in emergency digestive endoscopy diagnosis and treatment. Methods Seventy-eight cases underwent acute digestive endoscopy in our hospital were selected as the research object, and according to the random number table method divided into observation group and control group. For the control group, 39 patients was given routine nursing, and for the observation group, 39 patients was implemented additionally seamless docking nursing. The two groups were observed and compared after treatment of anxiety self-rating scale (SAS) and self-rating depression scale (SDS) score, the incidence rate of adverse reaction and nursing satisfaction. Results The SAS and SDS scores were 48.3±5.1 and 48.9±6.2 before nursing in the patients of the observation group, and the SAS and SDS scores were 24.1±4.9 and 25.8±3.1 after nursing. The SAS and SDS score of the patients in the observation group after nursing were decreased. The SAS and SDS score were 49.6±4.7 and 48.5±6.7 before nursing in the patients of the control group, and the SAS and SDS score were 37.8±5.0 and 35.3±6.2 after nursing. The SAS and SDS score scales of the patients in the control group after nursing were decreased. The two scores in the patients in the observation group after nursing were significantly lower than those in the control group, and the above data within and between groups were significantly higher (all P<0.05). The degree of nursing satisfaction in the observation group (97.44%) was significantly higher than that of the control group (82.05%). The incidence of adverse reactions was significantly lower than that in the control group (5.13% vs. 12.82%), but the difference between the two groups were no significant difference (P=0.235). Conclusion Implementation of seamless docking nursing effect in the acute treatment of gastrointestinal endoscopy in patients can significantly alleviate the negative emotions of patients, improve the clinical nursing satisfaction, shorten treatment time.