运动对抑郁症症状、认知功能和γ-氨基丁酸影响的对照研究

杜远; 王龙; 张许来; 刘宝贵; 戴兢; 吴惠玲; 薛扬; 胡宏燕; 刘金同

doi:10.16766/j.cnki.issn.1674-4152.000994

运动对抑郁症症状、认知功能和γ-氨基丁酸影响的对照研究

doi: 10.16766/j.cnki.issn.1674-4152.000994

杜远^1,2,
王龙²,
张许来²,
刘宝贵²,
戴兢²,
吴惠玲²,
薛扬²,
胡宏燕²,
刘金同^1, ,

1. 山东大学临床医学院, 山东济南 250014;
2. 安徽省精神卫生中心情感障碍科, 安徽合肥 230022

基金项目:

安徽省重点研究与开发计划项目(201904a07020009)

详细信息

通讯作者:
刘金同,E-mail:jintongliu@sdu.edu.cn

中图分类号: R749.05;R395
计量
- 文章访问数: 146
- HTML全文浏览量: 25
- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2019-04-23
- 网络出版日期: 2022-08-05

Control study of exercise' influence on depression's symptom, cognitive function and GABA

Medical College, Shandong University, Jinan, Shandong 250014, China

摘要

摘要: 目的探讨运动行为干预对抑郁症症状和认知功能的影响，同时检测抑郁症患者体内γ-氨基丁酸(GABA)神经递质的变化，探讨运动干预改善抑郁症可能的生化机制。方法选取2018年11月—2019年4月安徽省精神卫生中心住院的65例成年抑郁症患者予以编号，然后采取抽签法抽取号码随机分组，分为干预组(35例)和对照组(30例)，5例干预组患者脱落。干预组运动方法为在跑步机上接受每周3~5次,每次35 min左右的慢跑有氧运动，运动时间为6周。运动前做10 min左右的热身运动，慢跑20 min左右，最后做5 min左右的缓慢运动。运用跑步机测量患者运动前后心率，使患者的最高训练心率能够控制在(220-年龄)×70%。干预组和对照组同时服用抗抑郁药物舍曲林(最大剂量为150 mg/d)治疗。采用汉密尔顿抑郁量表(HAMD)评分评估抑郁症症状，采用蒙特利尔认知评定量表(MoCA)评估认知功能，采用酶联免疫吸附试验法测量人体血浆中γ-氨基丁酸含量。2组间比较采用独立样本t检验，组内治疗前后比较采用配对样本t检验。结果对照组治疗前后HAMD分数差值为(-32.73±4.71)分，干预组治疗前后HAMD差值为(-24.23±8.95)分，运动结合抗抑郁药物治疗后抑郁症状显著改善(P<0.01)；对照组MoCA总分为(21.77±1.47)分，干预组MoCA总分为(25.23±1.16)分，运动结合抗抑郁药物治疗后认知功能显著改善(P<0.01)；对照组GABA浓度治疗前后差值为(0.32±1.54)mg/L，干预组GABA浓度治疗前后差值为(1.87±0.73)mg/L，运动结合抗抑郁药物治疗后GABA浓度明显上升(P<0.01)。结论运动干预可以改善抑郁症症状和认知功能，可以提高体内GABA含量。
- 运动 /
- 认知功能 /
- γ-氨基丁酸 /
- 抑郁症
Abstract: Objective To explore the effects of exercise on the symptoms, cognitive function and GABA in depression, as well as the possible biochemical mechanisms of exercise intervention in depression. Methods A total of 65 adult patients with depression from Anhui Mental Center were selected and numbered. Then the numbers were randomly divided by the lottery method. Patients (n=65) were divided into intervention group (n=35) and control group (n=30).5 patients in intervention group became detached. The intervention group took aerobic exercise on a treadmill about 35 minutes per day in a frequency of 3 to 5 times a week for 6 weeks. The whole exercise included a warm-up exercise for about 10 minutes before exercise, jogging for about 20 minutes, and a slow-down exercise for about 5 minutes. The heart rate of the patient was measured by using a treadmill before and after exercise, and the patient's highest training heart rate was controlled at (220-age)×70%. Besides, both of the intervention and the control group were treated with antidepressant sertraline (maximum dose of 150 mg/d). Depression symptoms were assessed by the Hamilton Depression Rating Scale. Cognitive function was assessed by the Montreal Cognitive Rating Scale. The GABA levels in human plasma were measured by enzyme-linked immunosorbent assay. The t-test of independent samples was used to compare sample data before and after treatment for the same group, while the t-test of paired samples were adopted for inter-group data. Different data were compared by the obtained means and variances. Results The difference of HAMD reduction scores were (-32.73±4.71) for the control group and (-24.23±8.95) for the intervention group. Total score of MoCA in the control group was (21.77±1.47), and in the intervention one was (25.23±1.16). The difference of GABA concentration in the control group before and after treatment was (0.32±1.54) mg/L, and in the intervention group was (1.87±0.73) mg/L. Exercise combined with antidepressant drugs significantly relieves depressive symptoms (P<0.01). Conclusion Exercise can relieve depressive symptoms and improve cognitive function of depression and increase the GABA levels in human plasma of depression.
- Exercise /
- Cognitive functions /
- GABA /
- Depression