Abstract: Objective To investigate the application value of comprehensive rehabilitation in patients with craniocerebral trauma. Methods A total of 104 patients with craniocerebral trauma who were treated with emergency surgery in our hospital from October 2016 to May 2018 were selected as subjects. They were randomly divided into observation group (51 patients) and control group (53 patients). The observation group was treated with comprehensive rehabilitation and routine rehabilitation in the control group. The χ² test was used to compare the incidence of common complications during hospitalization between the two groups. The t-test was used to analyze the FMA motor function score (Fugl-Meyer, FMA) and BI Daily living Ability Score (Bathel Index, BI) of the two groups after half a year，then the application value of comprehensive rehabilitation treatment programs was evaluated. Results The incidence of common complications during hospitalization was 27.45% in the observation group and 54.72% in the control group. After half a year of rehabilitation, the FMA score and BI score of the observation group were 83.18±2.24 and 72.71±2.99, and the control group was 76.15±2.33 and 63.60±3.31. χ² test showed that the incidence of common complications in the observation group was significantly lower than that of the control group (P=0.039). While the t-test showed that the FMA score and BI score in the observation group were significantly higher than the control group (P=0.032, 0.044). Conclusion Comprehensive rehabilitation treatment can significantly reduce the incidence of common complications in patients with craniocerebral trauma, and also promote the recovery of function and improve the quality of life, which has a certain clinical application value.