Abstract: Objective To investigate the efficacy of subcutaneous injection of Nadroparin calcium after replantation of digits on venous congestion of patients and complications. Methods Forty six patients (62 fingers) undergoing replantation of digits in our hospital between February 2016 and September 2018 were enrolled and divided into experimental group (23 cases) and control group (23 cases) by random number table method. Nadroparin calcium was injected subcutaneously on the right or left side of the abdominal wall in the control group and on the replanted fingers in the experimental group. The swelling diameter and pain visual analogue scores (VAS) at 1 d, 5 d and 7 d after the surgery were compared between the two groups. The incidence of complications such as embolism, vasospasm and skin flap necrosis was compared. The levels of prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (thrombin time, TT), fibrinogen (Fibrinogen, FIB) and other coagulation indicators were compared between the two groups before and after treatment. Results The swelling diameter of the two groups at each time point was significantly lower than that before the treatment (P<0.05). Among them, the degree of swelling of the fingers in the experimental group was lower than that of the control group at 5 d and 7 d after the operation. VAS scores at 1 d, 5 d and 7 d of the experimental group were lower than those of the control group at the corresponding time points, and the difference was statistically significant (all P<0.05). The incidence of venous and total complications were significantly lower in the group than in the control group (all P<0.05). After the treatment, the levels of PT, APTT and TT in the control group increased significantly (all P<0.05). There was no significant difference in PT, APTT, TT and FIB in the experimental group before and after the treatment (all P>0.05). After the treatment, PT, APTT and TT in the control group were significantly higher than those in the experimental group (all P<0.05). There was no significant difference in FIB between the two groups before and after treatment (P>0.05). Conclusion Low-molecular-weight heparin calcium subcutaneous injection is effective in the treatment of venous congestion after replantation of severed fingers, which can significantly reduce the incidence of complications and has little effect on coagulation.