Abstract: Objective To observe therapeutic efficacy of intensive therapy with insulin analogues on newly diagnosed type 2 diabetes. Methods We select 58 newly diagnosed type 2 diabetes patients in hospital from 2013 to 2016. ALL 58 newly diagnosed type 2 diabetic patients were treated by insulin aspart before 3 meals combined with insulin glargine at bedtime. The dosage of insulin was adjusted according to blood sugar for 12 weeks. After 10-14 days of hospitalization, the patients' blood sugar reached the standard (fasting blood sugar<7 mmol/L, postprandial blood sugar<10 mmol/L) and were discharged. After discharge, the original regimen was continued for 12 weeks. The fasting blood glucose, fasting insulin, HbA1c, HOMA-IR, HOME-β, △I₃₀/△G₃₀, TCH, TG, LDL, HDL, systolic blood pressure, diastolic blood pressure, BMI and waist to hip ratio was observed at the baseline and the end of the trail. The change of each index was analyzed by paired t-test. Results After treatment, the levels of fasting blood glucose, fasting insulin, HbA1c, TCH, TG and LDL were significantly lower than those before treatment (all P<0.05); After treatment with HOME-β and △I₃₀/△G₃₀ increased significantly than before (all P<0.05); There was no statistical significance in the changes of systolic pressure, diastolic pressure, HDL, HOMA-IR, BMI and waist to hip ratio before and after treatment. Conclusion For the newly diagnosed type 2 diabetic patients, taking 12 weeks intensive insulin analogue therapy can control blood glucose well, improve the function of β-cells, and at the same time, it is safe and reliable.