Abstract: Objective To investigate the comorbidity of diabetes mellitus erectile dysfunction and depression in male patients with type 2 diabetes mellitus. Methods One hundred and fifty-six male DMED patients in our hospital from November 2015 to November to 2018 were enrolled, who were divided into group A (DMED with depression,105 cases) and group B (DMED without depression,51 cases) according to the results of Self-rating depression scale (SDS). The co-morbidity of DMED and depression was calculated, and the differences of baseline index, blood sugar control index, sex hormone index and lipid biochemical index between the two groups were compared. Pearson correlation analysis was used to evaluate the correlation between SDS scale score and these indexes, and Logistic regression analysis was carried out. Results Among 156 male patients with T2DM, 105 had depression, with a total incidence of 67.31%. The age of group A was significantly higher than that of group B, the duration of T2DM was significantly longer than that of group B, FPG, FIns and HbA1c were higher than that of group B, TT was lower than that of group B, LH and FSH were higher than that of group B, the difference was statistically significant (all P<0.05). Pearson analysis showed that SDS score was positively correlated with age, course of T2DM, FPG, Fins, HbA1c, LH and FSH, and negatively correlated with TT level (all P<0.05). Logistic regression analysis showed that age, duration of T2DM and TT level were independent risk factors for comorbidity of DMED and depression (all P<0.05). Conclusions In male T2DM patients, DMED has a comorbid condition with depression. Old age, long course of T2DM and low TT may be the independent risk factors for the comorbidity.