Abstract: The population problem is the key problem of the development of our country. With the release of a comprehensive second child policy, there is an increase in the number of women who want to have a second child. The age of women who have the need to reproduce is increasing with the influence of multiple factors such as social pressure. Older women with infertility become the most important component of infertile women, for the rate of female infertility increases with age. How to implement comprehensive second child policy and help the infertile couples, especially the older infertile couples, becomes a new challenge. Due to regional and quantitative limitations, specialized hospitals have been unable to meet the consultation and treatment needs of infertile patients. A general practitioner, as a physician who is based on the community and provides comprehensive services for individuals, families and communities, plays an important role in maintaining the health of the community. However, the knowledge and technology of infertility and assisted reproductive technology (ART) are still limited to specialized hospitals. Also, the knowledge and technology in this field mastered by general practitioners serving the community cannot meet the needs of infertile patients. If the general practitioner is able to understand the relevant knowledge of infertility and assisted reproductive technology, monitor the conditions of patients in time, provide consulting services and counsel patient psychology, also recommend patients to the professional institutions of reproductive medicine for more effective treatments. After that, they can play important roles in the second child policy and lay a solid foundation for the policy promotion. The purpose of this review is to systematically explore the clinical application of infertility and assisted reproductive technology, and to sort out relevant knowledge, so as to make general practitioners pay attention to and understand reproductive medicine, and to meet the needs of diagnosis, treatment and consultation for infertile patients in the community.