Abstract: Objective To study the clinical effect of warming needle moxibustion on scapulohumeral periarthritis and provide corresponding treatment reference. Methods A total of 120 patients with scapulohumeral periarthritis admitted to traditional Chinese medicine of Jiangsu Province from January 2018 to January 2019 were selected and randomly divided into control group and combined group with 60 cases in each group. The patients in the control group were treated with routine western medicine, while the patients in the combined group were treated with Warming Acupuncture and moxibustion on the basis of the control group. VAS visual pain score, Melle score and activity of daily living scale were used to evaluate the pain, joint activity and activity of daily living of the two groups before and after treatment. The shoulder joint function of the two groups was evaluated. The changes of serum calcitonin gene-related peptide (CGRP) and substance P (SP) levels were detected before and after treatment. The treatment of the two groups was measured. The results were compared between groups. Results There was no significant difference in pain score, shoulder joint function score, joint activity score, daily living ability score, serum CGRP and SP level between the two groups before treatment (all P>0.05); after treatment, the pain score, joint activity score, serum CGRP and SP level in the combined group were lower than those in the control group, while the shoulder joint function score and daily living ability score were significantly higher than those in the control group (all P<0.05). The total effective rate of the combined group was significantly higher than that of the control group (P<0.05). Conclusion Warm acupuncture and moxibustion can inhibit the abnormal expression of pain inflammatory factors, relieve pain symptoms of patients with scapulohumeral periarthritis, restore shoulder joint function, and have a better therapeutic effect.