Abstract: Objective To explore the application of organ-systems-centered joint teaching rounds in the practice and teaching of general practice under the mode of curriculum integration. Methods A total of 51 students from the general medical department of the First Affiliated Hospital of Bengbu Medical College from 2013 to 2015 were selected as the research subjects. They were divided into two groups, 25 students in the experimental group and 26 students in the control group. In the control group, conventional teaching method were carried out, the experimental group conducted the organ-systems-centered joint teaching rounds, then the examination results, patients' evaluation of interns, teachers' evaluation and students'self-identification were compared by means of examination and questionnaire survey. Results The comparison of test scores showed that the theoretical scores (62.76±3.23), skills scores (24.48±2.25) and overall scores (87.32±4.18) of the experimental group were significantly higher than those of the control group (all P<0.05). The results of the evaluation form showed that the experimental group was superior to the control group in professional knowledge (19.52±1.85), communication ability (19.44±2.10) and clinical thinking ability (19.64±1.89) all P<0.05. The results of the patient evaluation form showed that the professional quality (26.04±1.51) and humanistic care (25.96±1.97) of the experimental group were better than those of the control group(all P<0.05).The results of self-evaluation form showed that the experimental group is superior to the control group in professional quality (14.08±1.04), humanistic care (13.88±6.75), teamwork (14.12±1.36) and future planning(14.44±1.26), all P<0.05. Conclusion The application effect of organ-systems-centered joint teaching rounds is better in the practice and teaching of general practice.