Abstract: Objective To explore the effect of continuous nursing intervention based on Wechat platform on psychological resilience and stigma of breast cancer patients. Methods Sixty cases of patients with radical mastectomy were divided into observation group (July to December 2017) and control group (January to June 2017) according to the order of admission. The control group was given continuous nursing by telephone after discharge, while the observation group was given continuous nursing by Wechat platform. Psychological resilience, stigma score and quality of life were compared between the two groups. Results The scores of CD-RISC in the observation group at 3 months and 6 months after discharge were 60.87±4.82 and 67.46±5.68, higher than those in the control group which were 54.36±4.78 and 53.25±4.73, respectively. The scores of SIS in the observation group were 61.37±10.32 and 55.89±11.21, lower than those in the control group which were 69.85±12.04 and 70.31±11.94, respectively (all P<0.05). The quality of life scales (FACT-B) of breast cancer in the observation group for one month, three months and six months after discharge were 105.26 ±14.71, 114.21 ±14.08, 120.91±14.07, higher than those in the control group which were 92.26±19.42, 104.23±16.85, 109.02±13.78, with significant difference (all P<0.05). Conclusion Continuous nursing based on Wechat platform can improve the psychological resilience level, reduce the sense of shame and improve the quality of life of patients with breast cancer after radical mastectomy.