Abstract: Objective To explore the effect of systematic nursing intervention on the related indicators of pregnant women infected with group B Streptococcus (GBS). Methods A total of 140 parturients with GBS infection who were treated in our hospital from May 2016 to May 2017 were selected and divided into general nursing group and systematic intervention group according to random number method. Routine nursing was given to general nursing group and systematic nursing intervention group. The psychological status, quality of life and self-care ability of the two groups before and after nursing were evaluated, and the hospitalization time, nursing quality, adverse pregnancy outcomes, adverse neonatal outcomes and satisfaction degree of patients' family members were statistically compared between the two groups. Results The scores of HAMD and HAMA in the systemic intervention group were (13.88±4.13) and (12.61±4.11) respectively, lower than those in the general nursing group (17.65±4.56), (16.58±4.46). The scores of quality of life were (64.63±5.06), higher than those in the general nursing group (60.54±4.97, all P<0.05). The scores of self-care ability in the intervention group after nursing were higher than those in the general nursing group (all P<0.05). The average hospitalization time in the systemic intervention group was (4.56±0.38) days, which was shorter than that in the general nursing group (5.32±0.57) days. The nursing quality score was (93.53±7.21), which was higher than that in the general nursing group (86.77±6.59, all P<0.05). The incidence of adverse pregnancy outcomes in the intervention group was 4.29%, lower than that in the general nursing group 17.14%(P<0.05). The incidence of adverse neonatal outcomes in the intervention group was 13.51%, which was lower than that in the general nursing group 34.25% (P<0.05). The total satisfaction rate of family members in the intervention group was 95.71%, higher than that in the general nursing group 84.29% (P<0.05). Conclusion Systematic nursing intervention for GBS infected parturients can improve patients' life and psychological status, enhance patients'self-care ability, improve patients' pregnancy outcomes, and make patients and their families more satisfied.