Abstract: Objective To analyze the effect of comprehensive nursing intervention on Chinese medicine treatment of patients with psoriasis, and provide clinical reference. Methods A total of 102 patients with psoriasis admitted to our hospital from August 2017 to May 2018 were enrolled in the study. They were divided into two groups using a random number table method, with 51 patients in each group. Among them, patients with psoriasis in the routine nursing group were given routine nursing intervention, and patients in the comprehensive nursing group were given comprehensive nursing. The patient's treatment comfort, self-efficacy, stress, coping style, quality of life and social anxiety were compared and analyzed. Results The comfort level of patients with psoriasis in the comprehensive nursing group (8.71±0.66) was higher than that in the conventional nursing group (6.87±0.57), and the self-efficacy (35.11±5.12) was higher than that in the conventional nursing group (30.87±6.22), all P<0.05; the comprehensive nursing group patients'stress level (30.76±1.55) points was lower than the conventional nursing group (37.87±1.78) points, and the various dimensions of the stress source were lower than the conventional ones. In the nursing group, the scores of the coping styles were lower than the conventional nursing group, all P<0.05; the total quality of life and the dimensions of the psoriasis patients in the comprehensive nursing group was higher than the quality of life and psoriasis of psoriasis patients in the routine care group, all P<0.05; the social anxiety level of the comprehensive nursing group (35.53±8.12) was significantly lower than that of the conventional nursing group (41.44±7.54), P<0.05. Conclusion Comprehensive nursing can improve the comfort of patients with psoriasis during TCM treatment, improve self-efficacy, reduce stress level and social anxiety, and further improve the quality of life of patients with psoriasis. It is worth applying.