Abstract: Objective To explore the effect of transradial percutaneous coronary intervention (PCI) and early PCI after intravenous thrombolysis on cardiac function in patients with ST-segment elevation of acute myocardial infarction (STEMI) and the application value of early PCI. Methods Ninety-two patients were admitted successively From January 2016 to January 2017，in the First Affiliated Hospital of Bengbu Medical College.they were divided into emergency PCI group (76 cases) and early PCI group (16 cases) after intravenous thrombolysis. The clinical efficacy, the left ventricular end-diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF), and the incidence of compound cardiovascular events of the two groups were analyzed. Results There was no significant difference in baseline results between the two groups. The TIMI 3 level of coronary artery blood flow in the early PCI group was significantly higher than that in the emergency PCI group (93.7% vs. 78.9%, P<0.05). After 12 months of follow-up, there was no significant difference in LVEDI (102.2±15.3 vs. 97.6±21.5), LVEF [(43.6±7.8)% vs. (46.5±5.7)%] and compound cardiovascular events (6.6% vs. 6.3%) between the two groups (all P>0.05). Conclusion For STEMI patients who were diagnosed in primary hospitals without emergency intervention conditions, it is safe and effective to transport them to superior hospitals in time for PCI in early stage after thrombolysis. It does not affect the recovery of cardiac function and do not increase the occurrence of compound cardiovascular events.