Abstract: Objective To investigate the correlation between bone mineral density (BMD) and serum thyroid stimulating hormone (TSH) levels in postmenopausal women with type 2 diabetes mellitus (T2DM). Methods A total of 267 postmenopausal women with T2DM admitted to the Department of Endocrinology of Wenzhou Integrated Traditional Chinese and Western Medicine Hospital between October 2015 and October 2018 were selected as the subjects of study, according to TSH value, the patients were divided into three groups: A (81 cases), B (94 cases) and C (92 cases).The basic data (age, age of menopause, menopause, duration, body mass index BMI, blood pressure), biochemical indicators (fasting blood glucose, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, High-density lipoprotein cholesterol, alkaline phosphatase, 25-hydroxyvitamin D, blood calcium, blood phosphorus) and thyroid function (free triiodothyronine, free tetraiodothyronine, total triiodothyronine, total tetraiodothyronine, thyroid stimulating hormone) were collected, and bone mineral density of L_2-4, femoral neck and total hip were measured. The basic data, biochemical parameters, thyroid function and bone mineral density of L_2-4, femoral neck and total hip were compared among the three groups, and the correlation between TSH and BMD was analyzed. Results The serum TSH of patients in group A, B and C increased in turn (P<0.05). The BMD of L_2-4, femoral neck and total hip increased in groups A, B and C (all P<0.05). Person correlation analysis showed that serum TSH was positively correlated with L_2-4, femoral neck and total hip BMD (r=0.535, 0.774, 0.813, P=0.007, 0.014, 0.023). Conclusion The serum TSH level was positively correlated with bone mineral density in postmenopausal women with normal thyroid function.