Abstract: Objective To explore the effects of self-confidence training on mental state in patients with depression during convalescence. Methods Eighty patients with depression selected from January 2017 to December 2018 in our hospital were randomly divided into observation group (40 cases) and control group (40 cases) using the method of random sampling. The control group was given routine treatment, while the observation group was given self-confidence training intervention on the basis of control group. The self-rating anxiety scale (SAS), self-rating depression scale (SDS), feelings of inadequacy scale (FIS), self-esteem scale (SES), trust scale and the coping style questionnaire scores were compared between two groups. Results Before treatment, there were no significant differences in the scores of SAS, SDS, SES and FIS between the two groups (all P>0.05). After treatment, the SAS and SDS scores of the observation group were significantly decreased and lower than the control group, while the SES and FIS scores were significantly higher than the control group (all P<0.05). The dependability, predictability, trust, and total scores of the observation group were significantly higher than those of the control group (all P<0.05). The problem solving, help-seeking and rationalization scores of the observation group were significantly higher than the control group, and the self-blame, retreat and fantasy scores were significantly lower than the control group (all P<0.05). Conclusion Self-confidence training is helpful to improve depression and anxiety during convalescence, enhance the self-esteem and self-confidence. This training can effectively promote overall recovery, and help patients return to society, which has good promotion and application value.