Abstract: Objective To investigate the role of Jiajian Baohe Decoction in the recovery of intestinal function after total gastrectomy. Methods A total of 120 patients with pathologically confirmed gastric cancer and total gastrectomy in Zhejiang Cancer Hospital from July 2015 to June 2017 were enrolled. According to the random sequence number, the study group and the control group were divided into 60 cases. The study group began to give Jiajian Baohe Decoction 200 mL nasal feeding twice a day within 24 hours for 3 consecutive days, and the control group was given 200 mL saline nasal feeding. The postoperative venting and defecation time, postoperative abdominal pressure, postoperative serum concentration of somatostatin, cholecystokinin and IL-6 were compared between the two groups. Results The postoperative venting time (3.20±0.73) d vs. (3.58±0.92) d and defecation time (4.40±0.85) d vs. (4.87±1.35) d in the study group were shorter than those in the control group. The postoperative abdominal pressure of study group on D1 (10.38±3.51) cm H₂O vs. (13.47±6.51) cm H₂O, D2 (11.57±4.43) cm H₂O vs. (13.46±5.58) cm H₂O, D3 (10.15±4.41) cm H₂O vs. (12.06±4.98) cm H₂O was lower than that of the control group. The serum concentration of somatostatin (17.09±6.66) pg/mL vs. (20.36±9.76) pg/mL and IL-6 (11.53±4.13) pg/mL vs. (13.69±5.89) pg/mL on postoperative D7 in the study group lower than that of the control group. And the serum cholecystokinin(CCK) concentration of postoperative D7 (110.18±53.21) pg/mL vs. (70.42±31.97) pg/mL In the study group was higher than that of the control group. There were no significant differences in the serum concentration of CCK, IL-6 and somatostatin on postoperative D0, D1 and D3 between the two groups. Conclusion The Jiajian Baohe Decoction in patients undergoing total gastrectomy has a significant effect on the recovery of intestinal function.