Abstract: Objective To investigate effect of Biaoben Acupoints acupuncture on patients with post-stroke dysphagia, so as to provide an effective theoretical basis for the treatment. Methods A total of 148 cases of post-stroke dysphagia treated in our hospital from February 2016 to February 2018 were selected and randomly divided into two groups, each with 74 cases. The control group received routine medical treatment and rehabilitation training. Based on this, the study group received the Biaoben Acupoints acupuncture. Then the clinical efficacy, Watian drinking test rating, swallowing function improvement (SSA score), TV perspective swallowing function (VFSS score) and quality of life (SWAL-QOL score) and the adverse reactions of the two groups were compared. Results ①The total effective rate of the study group after treatment was significantly higher than that of the control group (94.59% vs. 83.78%, P<0.05); ②The SSA scores between the two groups had no difference before treatment (P>0.05), and the SSA scores decreased in both groups, which were significantly lower in the study group than in the control group (all P<0.05); ③The water swallow test results between the two groups were ameliorated in both groups after treatment (all P<0.05), which were significantly better in the study group than in the control group (all P<0.05). ④There was no significant difference in VFSS scores and SWAL-QOL scores between the two groups before treatment(all P>0.05). The VFSS and SWAL-QOL scores in the two groups were higher than those before the treatment, and the VFSS score and the SWAL-QOL score in the study group were all higher than those in the control group (all P<0.05); ⑤The overall incidence rate of adverse reactions in the study group was slightly lower than that in the control group (4.05% vs. 5.41%, P>0.05). Conclusion Biaoben Acupoints acupuncture can effectively and safely ameliorate the swallowing function for patients with post-stroke dysphagia, which has less adverse reaction.