Abstract: Objective To observe the clinical effect of Qingre Xiaocuo Decoction combined with fumigation in the treatment of moderate and mild acne vulgaris of lung meridian and wind-heat type. Methods A total of 124 patients with moderate and mild acne vulgaris of lung meridian wind-heat type in the Jiaxing Hospital of Traditional Chinese Medicine from August 2017 to August 2018 were divided into control group (n=62) and research group (n=62) according to random digital form. The control group was treated with retinoic acid combined with minocycline hydrochloride, while the research group was treated with Qingre Xiaocuo Decoction combined with fumigation. The TNF-α, IL-6 and IL-8 levels in serum were measured, the onset time of acne lesion reduction after treatment was counted, the adverse drug reactions were observed during treatment, the curative effect was evaluated, and the recurrence was followed up within 6 months. Results The levels of serum TNF-α, IL-6 and IL-8 in the research group were lower than those in the control group after treatment (P<0.05). The onset time of acne lesion reduction in the research group (10.72±2.47) d were shorter than those in the control group (15.31±4.10) d (P<0.05). There was no significant difference in the overall effective rate between the research group (93.55%) and the control group (88.71%) (P>0.05). The recurrence rate of acne vulgaris in the research group (10.34%) was lower than that in the control group (25.45%, P<0.05). The overall incidence of adverse drug reactions in the research group (4.84%) was lower than that in the control group (16.13%, P<0.05). Conclusion Both traditional Chinese and Western medicine can effectively improve clinical symptoms of moderate and mild acne vulgaris of lung meridian wind-heat type. However, Qingre Xiaocuo Decoction combined with fumigation can significantly reduce the intensity of inflammatory reaction, shorten the disease control cycle, prevent the recurrence of acne, and have fewer adverse reactions.