Abstract: Objective To explore the influence of peer education based on WeChat platform on psychological, self-care ability and quality of life in patients with liver cancer after interventional therapy. Methods One hundred and twelve patients with liver cancer intervention in Zhejiang Hospital from June 2017 to June 2018 were selected as research subject and divided into 2 groups according to random number method, 56 cases in each group. The control group was received postoperative routine nursing intervention. The observation group was added peer education nursing intervention based on WeChat platform. Both groups were nursed 4 weeks after discharge. Before and after nursing, the depression self-rating scale (SDS) and anxiety self-rating scale (SAS) were used to evaluate the depression and anxiety of the two groups. The self-care ability measurement scale (ESCA) was used to evaluate the self-concept of the two groups. Self-care ability in health knowledge, self-care skills and self-responsibility. The QOL-30 quality of life scale was used to evaluate the life quality of the two groups in terms of physiological function, psychological function, physical function and social function. Results After nursing, the SDS and SAS scores of the two groups were significantly decreased compared with the control group (P<0.05). After nursing, the self-concept, health knowledge, self-care skills and self-responsibility scores of the two groups were significantly increased compared with the control group (P<0.05). After nursing, the physiological function, psychological function, physical function and social function scores of the two groups were significantly increased compared with the control group (P<0.05). Conclusion Peer education based on WeChat platform can alleviate the depression and anxiety state of, improve the self-care ability of patients, and improve the life quality of patients with liver cancer after interventional therapy.