Abstract: Objective To study the effect of personalized nursing combined with psychological induction in the recovery period of patients with gastric cancer after operation. Methods Ninety patients with gastric cancer underwent laparoscopic surgery in Wuhan NO.6 Hospital from October 2017 to April 2018 were selected and divided into conventional nursing group, personalized nursing group and psychological combined group by random number method, with 30 cases in each group. The first exhaust time and hospitalization time of the three groups were counted. The psychological status, sleep quality and quality of life of the three groups were compared before and after nursing. The compliance of the three groups in nursing process was evaluated, and the nursing satisfaction of the three groups was investigated. Results The exhaust time and hospitalization time of the combined group were lower than those of the other two groups (P<0.05). The SAS scores of the three groups were lower than those before the nursing (P<0.05). The SDS scores of the conventional nursing group and the personalized nursing group were slightly lower than that before nursing (P> 0.05). The SAS and SDS scores of the psychological combined group were significantly lower than those before nursing, and lower than those of the other two groups (P<0.05). There was no significant difference in AIS and QOL scores before and after nursing in conventional nursing group (P>0.05). The AIS scores and quality of life scores of the patients in the personalized nursing group were slightly better than those before the nursing (P>0.05). The AIS and QOL scores in psychological combined group were better than those before nursing, and better than those of other two groups (P<0.05). The compliance rate and nursing satisfaction rate of the psychological combined group were higher than those of the other two groups (P<0.05). Conclusion Personalized nursing combined with psychological induction can reduce the negative emotions during the recovery period, improve the patient's nursing compliance, the quality of life and sleep of patients, which is widely recognized by patients and their families.