Abstract: Objective To explore the attentional damage of patients with Wilson's disease (WD) by attentional network test. Methods Thirty patients with WD admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine from June 2016 to June 2019 were selected to perform the attentional network test, as well as 30 gender, age, and education-matched healthy controls. The alert network efficiency, the directional network efficiency, the executive control network efficiency, the total average reaction time and the total accuracy were compared by the attentional network test. Results In WD group, the alert network efficiency, the directional network efficiency, the executive control network efficiency, the total average reaction time and the total accuracy were (21.53±8.98) ms, (30.50±10.11) ms, (104.03±18.96) ms, (601.63±75.96) ms and (97.43±2.57)%, respectively. Meanwhile, in control group, the alert network efficiency, the directional network efficiency, the executive control network efficiency, the total average reaction time and the total accuracy were (37.17±10.70) ms, (32.57±9.58) ms, (101.43±16.14) ms, (540.03±49.54) ms and (98.07±1.57)%, respectively. The alerting network efficiency of WD group was lower than that of control group (P<0.05), but the total average reaction time of WD group was longer than that of healthy control group (P<0.05). There was no significant difference in the directional network efficiency, the executive control network efficiency and the total accuracy between two groups (all P>0.05). Conclusion WD patients have attention network dysfunction, and the main performance is that the alert network is damaged, the directional network and the executive control network are normal.