Abstract: Objective To investigate the effect of Zishui Qinggan decoction on perimenopausal syndrome (MPS) women with syndrome of renal deficiency and hepatic stagnation. Methods Sixty-four MPS cases were selected in our hospital and divided into the control group and the observation group with 32 cases in each according to random number table method. Control group was treated with the routine therapy according to the guideline. On basis of control group, the observation group was treated with Zishui Qinggan decoction (1 dose / d and 2 times / d). Both groups were treated for 3 months. Scores of symptoms of syndrome of renal deficiency and hepatic stagnation and Kupperman index (KI), blood lipid levels, the efficacy, vascular endothelial function, and serum levels of adiponectin, Kisspeptin-10, and estradiol were compared between two groups. Results After 3 months treatment, scores of symptoms of syndrome of renal deficiency and KI, levels of triglyceride (TG), total cholesterol (TC), and high-density lipoprotein cholesterol (LDL-C) were significantly lower than those of the control group, while high-density lipoprotein cholesterol (HDL-C) were significantly higher than the control group (all P<0.01). Total effective rate of observation group (96.88%) was obviously higher than the control group (75.00%) , P<0.05. Serum levels of vascular hemophilia factor (vWF) and endothelin-1 (ET-1) in the observation group were significantly lower than those in the control group (P<0.01). Serum levels of adiponectin, Kisspeptin-10, and estradiol [(8.69±0.92) mg/L, (2.31±0.27) ng / L, (72.45±8.9) pmol/L] in the observation group were higher than those in the control group (all P<0.01). Conclusion The efficacy of Zishui Qinggan decoction in the treatment of perimenopause female patients with kidney deficiency and hepatic stagnation is significant. Up-regulation of serum levels of adiponectin, Kisspeptin-10, and estradiol may be one of the effective ways.