Abstract: Objective To investigate the suicide attitudes in patients with depression combined with anxiety disorder, and to explore the relationship with illness conditions and coping styles. Methods One thousand depressive patients with depression combined with anxiety disorder from June 2015 to June 2018 were selected as the combination group. In addition, 600 patients with depression and 600 patients with anxiety were selected as depression group and anxiety group. All the patients were investigated with QSA, SCSQ, SDS and SAS. The scores of suicide attitudes, illness conditions and coping styles among the 3 groups were compared. Pearson correlation analysis was used to explore the correlation between suicide attitudes, illness conditions and coping styles in the combination group. Results The scores of suicide attitudes and positive coping in the combination group (19.43±2.01, 20.07±2.11, 11.06±2.01, 11.01±1.85, 17.12±2.07)were significantly lower than those in the depression group and the anxiety group (all P<0.05). The SDS (65.85±3.95) and SAS (65.38±3.37) in the combination group were lower than those in the depression group and the anxiety group (all P<0.05). The negative coping score (13.56±1.50) in the combination group was higher than those in the depression group and the anxiety group (all P<0.05). There were negative correlations between suicidal attitudes in F1, F2, F3 and F dimensions with SDS, SAS and negative coping (all P<0.05). There were positive correlations between the above dimensions of suicide attitudes and positive coping (all P<0.05). Conclusion Understanding of suicidal behavior, attitude toward suicide, attitude toward suicide family members, and attitude rejection toward euthanasia of depressive patients with anxiety disorder are not obvious, which are significantly correlated with illness conditions and coping styles.