Abstract: Objective To observe the nursing intervention effect of Comprehensive Age Assessment (CGA) in elderly patients with COPD combined with anxiety/depression. Methods From June 2015 to December 2017 in Department of Respiratory Medicine in Shaoxing People's Hospital, 128 elderly patients (≥60 years old) with anxiety/depression status were included. All patients were divided into control group (64 cases) and observation group (64 cases) by random number table method, and routine nursing and CGA mode nursing were performed, respectively. The daily living ability, social activity ability and anxiety/depression state of the two groups before and after nursing were compared. Results After the nursing, the daily life ability score (2.55±0.16) and the improvement of the social activity ability score (1.97±0.34) in the observation group were all significant improvement than those of the control group [(1.78±0.30)and (1.47±0.24)] (t=12.348, 9.611, all P<0.001). The anxiety/depression symptom scores were improved [(2.31±0.36)/(2.93±0.52)]in the observation group than those in the control group (1.65±0.30) scores/(1.97±0.24) scores] (t=11.267, 13.410, all P<0.001). Conclusion The comprehensive age assessment intervention for elderly patients with COPD complicated with anxiety/depression can effectively relieve the adverse mood of anxiety/depression and improve their quality of life.