Abstract: Objective To explore the effect of personalized health education on treatment compliance and asthma attack frequency of school-age children with asthma. Methods A total of 110 school-age children with asthma were selected from May 2017 to March 2019. They were divided into observation group and control group according to random number table method, 55 cases in each group. The patients in the control group were given routine nursing, while the patients in the observation group were given individualized health education on the basis of the control group. Compare the treatment compliance, asthma attack frequency, self-management ability and pulmonary function before and after intervention between the two groups. Results After intervention, Daily dosage score, Medication time score, Number of medications score and compliance behavior score in the observation group were (4.06±0.11), (4.21±0.13), (4.15±0.27) and (3.98±0.46), respectively, which were significantly lower than that in the control group (3.21±0.17), (3.09±0.40),(3.22±0.16) and (3.02±0.41), the frequency of asthma attack in the observation group was (0.85±0.12) times per month, significantly lower than that in the control group which was (1.54±0.34) times per month, the difference was significant (all P＜0.05). Total score of self-management ability in the observation was (138.76±15.46), significantly higher than the control group (128.47±14.55), the difference was significant (P＜0.05). The scores of pulmonary function of children in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Individualized health education can significantly improve the treatment compliance and self-management ability of school-age children with asthma, effectively reduce the frequency of asthma attack and improve pulmonary function, which is worthy of clinical application.