Abstract: Objective To observe the effect of the acupoint catgut-embedding therapy which based on the theory of "interconnection of Zang-Fu viscera"on patients ' percentage(F%), body mass index(BMI) and serum total cholestrerol(TC), triglyceride(TG), high densitylipoprotin-cholesterol(HDL-C) of who with obesity and hyperlipidemia, and to observe the total effective rate and observed the recurrence rate after 3 months, meanwhile, to compare with the control group. Methods Seventy patients with obesity and hyperlipidemia were selected who were diagnosed in Jinhua hospital of traditional Chinese medicine from January 2016 to October 2018, and randomly divided into the embedding group and the control group. Embedding group acupoints were selected Wangu, Sanjiaoshu, Geshu, Daimai, Tianshu, Shuidao, Fenglong, and was treated by sterilized No.2-0 catgut embedding once per week, 2 times per course. Control group acupoints were selected the same as embedding group, filiform needles were sticked into acupoints 5 times per week, 10 times per course. After 3 courses of treatment, F%, BMI, values of serum TC, TG, HDL-C were evaluated and compared. We also compared the total effective rate and observed the recurrence rate after 3 months. Results After treatment, the embedding group's total effective rate and recurrence rate were obviously better than those of control group (P<0.05). The values of BMI, F%, TC, TG of embedding group were lower than those of control group (P<0.05), which of the HDL-C were higher than control group (P<0.05). Conclusion The acupoint catgut-embedding therapy which based on the theory of "interconnection of Zang-Fu viscera", can effectively reduce the values of weight, BMI, F%, TC, TG, up-regulate HDL-C of patients with obesity and hyperlipidemia, which has better clinical efficacy, and can effectively reduce the recurrence.