Abstract: Objective To explore the effect of comprehensive nursing on multimodal analgesia during perioperative period of total hip arthroplasty (THA). Methods Fifty patients with THA admitted to our department from January 2015 to December 2016 were selected as the control group. Multimodal analgesia plus routine nursing was performed. Fifty patients with THA admitted to our department from January 2015 to December 2016 were selected as the observation group, who were used multimodal analgesia plus comprehensive nursing. The pain of patients at 6, 12, 24 and 48 hours after operation were investigated by digital scoring method. The adverse reactions and the use of additional analgesics at 48 hours after operation were counted. The hip flexion, abduction and Harris score were recorded at 1, 3 and 5 days after operation, and the patient's satisfaction with analgesia was investigated. Results The pain score of the observation group at 6, 12, 24 and 48 hours after operation was lower than that of the control group, and the addition of analgesics was less than that of the control group (all P<0.05). The flexion activity and abduction activity of the hip in the observation group were greater than those in the control group on the 1, 3 and 5 day after operation (all P<0.05). The Harris score of the observation group was higher than that of the control group one month after operation (P<0.05). Postoperative analgesia-related adverse reactions in the observation group were less than those in the control group, and the degree of satisfaction with analgesia was higher than that in the control group (all P<0.05). Conclusion The comprehensive nursing can improve the analgesic effect of multi-mode analgesia in total hip replacement, reduce the adverse reactions of analgesia, and promote early joint activity after operation.