Abstract: Objective To study the effect of optimized nursing path based on goal management on the patients undergoing hysteroscopic endometrial polypectomy. Methods A total of 170 patients who underwent hysteroscopic endometrial polypectomy were selected. According to the random number table method, the patients were divided into observation group and control group, 85 cases in each group. The patients in the control group were given routine nursing pathway, while the patients in the observation group were given optimized nursing pathway. The operation time, hospitalization time, incidence of complications during hospitalization, nursing quality score and quality of life score before and after nursing were compared between the two groups. All patients were followed up for 6 months, and the recurrence rate after operation was counted. Results The operation time of the observation group was (24.56±6.73) min, shorter than that of the control group (38.41±5.22)min (t=14.992, P＜0.05), the length of stay in the observation group was (2.57±1.33) days, which was also shorter than that in the control group (4.26±1.27) days (t=8.473, all P＜0.05)；The incidence of complications in the observation group was 3.5%, lower than 11.7% in the control group (χ²= 4.680, P＜0.05).The scores of operation skill level, problem-solving ability, nursing preciseness and nurse patient communication ability were all higher than those of the control group (t=15.421, 17.561, 11.128.13.153, 28.150, all P＜0.05); after nursing intervention, the scores of quality of life in the observation group included physiological function, physiological function, physical pain and general health.Health status, vitality, social function, emotional function and mental health were all higher than those of the control group (t=12.171, 6.292, 9.724, 15.958, 12.323, 32.562, 9.410, 6.947, all P＜0.05); the recurrence rate of the observation group was lower than that of the control group (χ²= 4.224, P＜0.05). Conclusion The optimized nursing path based on objective management can effectively reduce the operation time and hospitalization time of patients undergoing hysteroscopic endometrial polypectomy, improve the quality of nursing, reduce complications and recurrence rate, and is conducive to improving the quality of life of patients, which is worthy of clinical application.