Abstract: Objective To investigate the effect of prospective nursing intervention on fundus fluoroscopy (FFA) in ophthalmology clinics and to provide reference for clinical nursing of ophthalmology. Methods A total of 140 patients who underwent FFA examination in the ophthalmology clinic from June to September 2019 were enrolled in the study. According to the random number table method, 70 patients were divided into observation group and control group. Patients in the control group were treated with routine nursing intervention, and the observation group was treated with prospective nursing intervention on the basis of the control group. The incidence of adverse reactions after contrast, the psychological status scores of the two groups before and after intervention, the quality of nursing score and the satisfaction of nursing were compared. Results The incidence of adverse reactions after angiography in the observation group was 10.0% (7/70), which was lower than that in the control group (25.7%, 18/70), χ²=5.892, P<0.05. Before the nursing intervention, the mental state scores of the two groups (SAS, SDS)had no statistical significance, P>0.05. After nursing intervention, the SAS and SDS scores of the two groups were lower, but the scores of the observation group were significantly lower than those of the control group[(14.52±2.13) vs.(17.66±2.85), (15.37±2.81) vs. (18.26±2.76)], t=7.384, 6.139, all P<0.05. Compared with the control group, the nursing satisfaction of the observation group was 95.7% (67/70), which was higher than that of the control group (82.9%,58/70), χ²=6.048, P<0.05. Conclusion Prospective nursing intervention can effectively reduce the incidence of post-contrast adverse reactions in patients with FFA examination in ophthalmology clinics, which is beneficial to alleviate patients' bad mood, improve nursing quality and nursing satisfaction, and is worthy of clinical application.