Abstract: Objective To observe the relevance of serum C-reactive protein (CRP) level to the early hematoma volume and long-term neurological deficits in patients with spontaneous intracerebral hemorrhage (SICH), and to provide evi- dence for guiding the diagnosis and treatment of SICH. Methods From March 2017 to February 2018, 96 patients with SICH who were admitted to the Affiliated Hospital of Hangzhou Normal University were selected as the observation group, and 96 healthy persons as the control group. The serum CRP levels were measured on the 1st, 3rd, 7th day after the ad- mission of the observation group and on the day of physical examination of the control group respectively. The amount of cerebral hemorrhage in the observation group was calculated, and the degree of neurological deficit in observation group was evaluated one year after discharge. Results In the observation group, there were 45 cases in the small bleeding group, 34 cases in the medium bleeding group, and 17 cases in the large bleeding groups, respectively. The CRP level of the observation group got the highest on the 3rd day after the admission, which was (7. 84 ± 1. 16) mg/L, and then de- creased to (7. 13 ± 1. 13) mg/L on the 7th day, but was still higher than (5. 27 ± 1. 10) mg/L on the 1st day (F=132. 366, P< 0. 001). On the 1st and 3rd days after the admission, there were significant differences in serum CRP lev- els among different blood volume groups (all P< 0. 05). On the 1st, 3rd and 7th day after the admission, there were sig- nificant differences in serum CRP levels among different neurological deficit groups (all P< 0. 05). The levels of CRP in medium and severe neurological deficit groups were higher than those in light neurological deficit groups (all P< 0. 05). Conclusion The serum CRP level is closely related to early hematoma and long-term neurological impairment in patients with SICH. The elevated serum CRP level suggests a larger amount of hematoma and a more likely long-term neurological impairment.