Abstract: Objective To analyze the effects of white blood cell count to mean platelet volume ratio(WMR) on short-term outcomes and its predictive value in patients with large-artery atherosclerotic stroke, so as to provide the direction for diagnosis and treatment of the disease. Methods A total of 120 patients with large-artery atherosclerotic stroke who were admitted to Zhuji People's Hospital from May 2015 to July 2018 were selected and were divided into good prognosis group(n=65) and poor prognosis group(n=55) according to the short-term outcome of patients. The demographic characteristics, vascular risk factors, baseline blood pressure, the baseline NIH Stroke Scale(NIHSS) scores and laboratory examination indexes levels of all patients were collected. The influencing factors were analyzed by binary logistic regression, and the receiver operating characteristic(ROC) curve was drawn. The area under the ROC curve(AUC) was used to evaluate the predictive value of WMR for large-artery atherosclerotic stroke. Results Systolic blood pressure, baseline NIHSS score and WMR level were independent risk factors for poor short-term outcomes of large-artery atherosclerotic stroke(all P<0.05); The WMR ratio of the good prognosis group was 0.86±0.32, and that of the poor prognosis group was 1.01±0.25, The AUC value of WMR in predicting short-term outcomes of patients was 0.826. Conclusion Systolic blood pressure, baseline NIHSS score and WMR are the independent risk factors for poor short-term outcomes of patients with large-artery atherosclerotic stroke. WMR has a good predictive value in short-term outcomes of these patients.