外周血脂蛋白相关磷脂酶水平与糖尿病患者冠状动脉硬化斑块的相关性研究

刘莉; 吴钢; 吴庆; 周静; 方永有

doi:10.16766/j.cnki.issn.1674-4152.001170

外周血脂蛋白相关磷脂酶水平与糖尿病患者冠状动脉硬化斑块的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.001170

刘莉¹,
吴钢²,
吴庆³,
周静³,
方永有^4, ,

1. 惠州市第三人民医院心脏检测科, 广东惠州 516000;
2. 武汉大学人民医院心血管内科, 湖北武汉 430060;
3. 鄂州市中心医院(武汉大学人民医院鄂州医院)超声科, 湖北鄂州 436000;
4. 惠州市第三人民医院心内科

基金项目:

湖北省科学技术厅计划项目(2016CFB743)

详细信息

通讯作者:
方永有,E-mail:34203145@qq.com

中图分类号: R587.1;R816.2
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- 被引次数: 0
出版历程
- 收稿日期: 2019-05-21
- 网络出版日期: 2022-08-05

Study on the relationship between the level of Lp-PLA2 in peripheral blood and coronary atherosclerotic plaque in diabetic patients

LIU Li¹,
WU Gang²,
WU Qing³,
ZHOU Jing³,
FANG Yong-you^{4
, ,}

1. Department of Cardiac Detection, Huizhou Third People's Hospital, Huizhou, Guangdong 516000, China

摘要

摘要: 目的分析糖尿病患者外周血脂蛋白相关磷脂酶A2(Lp-PLA2)水平对于评估冠状动脉硬化斑块的价值。方法选择2015年2月—2018年10月在鄂州市中心医院行冠状动脉造影(CAG)检查的211例2型糖尿病患者为研究对象,根据结果将其分为非冠状动脉粥样硬化组(91例)和冠状动脉粥样硬化组(120例),分别为对照组和研究组。对比2组患者基线资料、实验室指标、血管内超声相关指标,就血浆Lp-PLA2水平与超声指标斑块负荷(PB)、Gensini评分、斑块数目、病变血管数目的相关性进行分析,应用多因素logistic回归分析影响2型糖尿病患者发生冠状动脉粥样硬化的因素。结果 2组患者年龄、身体质量指数(BMI)、高血压病史比较差异无统计学意义(均P>0.05);2组患者甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、总胆固醇(TC)比较差异无统计学意义(均P>0.05);对照组患者糖化血红蛋白(HbA1c)、血浆Lp-PLA2水平低于研究组(均P<0.05);研究组的最小管腔面积、最小血管直径小于对照组,而PB大于对照组(均P<0.05);血浆Lp-PLA2水平与PB、Gensini评分、斑块数目、病变血管数目呈正相关(均P<0.05)。结论高Lp-PLA2是影响2型糖尿病冠状动脉粥样硬化发生的危险因素,且与患者疾病的严重程度相关,Lp-PLA2的检测对于评估糖尿病患者冠状动脉硬化斑块的病情具有值得肯定的价值。
- 血管内超声 /
- 脂蛋白相关磷脂酶A2 /
- 冠状动脉硬化 /
- 糖尿病
Abstract: Objective To analyze the value of peripheral blood lipoprotein-related phospholipase A2(Lp-PLA2) levels in diabetic patients for the assessment of coronary atherosclerotic plaques. Methods A total of 211 patients with type 2 diabetes mellitus underwent coronary arteriography(CAG) in our hospital were enrolled as the object of study from February 2015 to October 2018. According to the results of the examination, they were divided into non-coronary atherosclerosis group(the control group, n=91) and coronary artery atherosclerosis group(the study group, n=120). Baseline data, laboratory indexes, and parameters of intravascular ultrasound were compared between the two groups. The correlation between plasma Lp-PLA2 level and patch burden(PB), Gensini score, plaque number and diseased vessel number were analyzed. Multivariate Logistic regression analysis was used to analyze the influencing factors of coronary atherosclerosis in patients with type 2 diabetes mellitus. Results There was no significant difference in age, body mass index(BMI), history of hypertension, triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), fasting plasma glucose(FPG), total cholesterol(TC) between the two groups(all P>0.05). The levels of glycosylated hemoglobin(HbA1 c) and plasma Lp-PLA2 in the control group were lower than those in the study group(all P<0.05). The minimum lumen area and minimum diameter of artery in patients of the study group were smaller than those in the control group, while PB in the study group was larger than those in the control group(all P<0.05). The Lp-PLA2 level in plasma was positively correlated with PB, Gensini score, number of plaques and number of pathological vessels(all P<0.05). Conclusion High Lp-PLA2 is a risk factor of coronary atherosclerosis in type 2 diabetes mellitus, and it is related to the severity of the disease. The detection of Lp-PLA2 has a positive value for the evaluation of the disease of coronary atherosclerotic plaque in diabetic patients.
- Intravascular ultrasound /
- Lipoprotein-associated phospholipase A2 /
- Coronary arteriosclerosis /
- Diabetes mellitus