Abstract: Objective To study the effect of antithrombotic pump combined with traditional Chinese medicine(TCM) in the treatment of lower extremity venous thrombosis in postmenopausal women after pelvic surgery. Methods One hundred patients with lower extremity venous thrombosis after pelvic surgery in our hospital from June 2018 to January 2019 were divided into control group and combined group with 50 cases each according to the random number table method. The patients in the control group were treated with antithrombotic pump, while the patients in the combined group were treated with TCM on the basis of the control group. The venous blood flow velocity, prothrombin time(PT), activated partial thromboplastin time(APTT), plasma fibrinogen(FIB), thrombin time(TT), D-dimer(D-dimer) of two groups were measured, and the symptoms of TCM were evaluated. The therapeutic effect, the rate of deep vein thrombosis and complications were evaluated and compared between the two groups. Results There were no significant difference in blood flow velocity, PT, APTT, FIB, TT, D-dimer level and TCM symptom score between the two groups before treatment(all P>0.05). After treatment, the blood flow velocity of right and left femoral vein in the combined group were faster than that of the control group(all P<0.05). The PT, APTT, TT time in the combined group were longer than that in the control group, the FIB, D-dimer level and TCM symptom score were lower than those in the control group(all P<0.05). The total effective rate of the combined group was higher than that of the control group(P<0.05). There was no significant difference in the incidence of complications between two groups(P>0.05). Conclusion Antithrombotic pump combined with TCM therapy can improve the coagulation function and venous blood flow velocity of lower extremities in postmenopausal women with lower extremity venous thrombosis after pelvic surgery, alleviate the symptoms of patients, and have a good clinical effect.