Abstract: Objective To investigate the clinical effect of self-made Danxiang Rupi Powder and Tianzhu Point Scraping in patients with liver stagnation and phlegm-type chyle and its influence on syndrome score and toxic side effects. Methods Eighty-four patients with liver stagnation and chyle-type chyle who were treated from March 2018 to March 2019 were enrolled. The random number table was divided into control group(n=42) and observation group(n=42). The control group was treated with self-made Danxiang granules and external application. The observation group was treated with Tianzong acupoint scraping on the basis of the control group. The effect of the patient was evaluated after 10 days of treatment. From the mass of the tumor, the extent of the tumor, the size of the tumor and the symptoms of the whole body. The scores of syndromes before and 10 days after treatment were evaluated. The levels of estradiol and progesterone in the follicular phase were determined by automatic biochemical analyzer. The syndrome scores, hormone levels and side effects were compared between the two groups. Results In the observation group, the mass of the mass(1.42±0.28), the extent of the tumor(1.41±0.27), the size of the mass(1.32±0.24) and the score of the systemic accompanying symptom(1.51±0.27) were lower than those of the control group.(t=13.249, 13.009, 13.296, 12.797, all P<0.05). Estradiol level [(121.39±10.23) pg/mL] in the follicular phase of the observation group was lower than that of the control group(t=4.562, P<0.05). Progesterone level [(14.64±1.48) ng/mL] was higher than that of the control group(t=8.125, P<0.05). Gastrointestinal reaction, blood pressure fluctuation, liver and kidney dysfunction, dizziness headache and other occurrences in the observation group and the control group after treatment were not statistically significant(P>0.05). Conclusion The self-made Danxiang sputum powder external application combined with Tianzong point scraping for liver stagnation and phlegm-type chyle reduces the syndrome score of patients, improves hormone levels, and does not increase the incidence of toxic and side effects, which is worthy of popularization and application.