Abstract: Objective To investigate the effect of social support on improving the quality of life of patients with mild head injury and provide a basis for the treatment of traumatic brain injury. Methods Seventy-six patients with mild craniocerebral trauma admitted to the Second Affiliated Hospital of Wenzhou Medical University from September 2017 to September 2018 were selected as subjects, according to the social support rate scale(SSRS) and self-made. The questionnaire was divided into 40 groups in the high group and 36 cases in the low group. The clinical data of the patients were collected and analyzed to improve the impact of social support on improving the quality of life of patients. Results The subjective support score, objective support score, support utilization score and SSRS total score of the high-group patients were significantly higher than the low-group corresponding scores. The difference between the groups was statistically significant(all P<0.05). The high-group patients were completely reviewed on time. The rate of incomplete follow-up was significantly higher than that of the low-group corresponding indicators. The rate of complete non-compliance was significantly lower than that of the low group. The difference between the groups was statistically significant(all P<0.05). The material life, physical function and psychological function of patients with high grouping were statistically significant. The social function and GQOLI-74 total score were significantly higher than those of the control group, and the difference between the groups was statistically significant(all P<0.05). Conclusion The social support for patients with mild craniocerebral injury can greatly improve the behavior of following the doctor's advice and quality of life. It has obvious promotion effect on the treatment and rehabilitation of patients, and the effect is more significant. The clinical effect can be improved by similar intervention. It can be further promoted and used clinically.