Abstract: Objective To investigate the effect of stent combined with laparoscopic surgery on the prognosis of colorectal cancer patients with obstruction. Methods According to the different operation methods, 98 colorectal cancer patients with obstruction admitted in our hospital from January 2009 to January 2013 were divided into the stent group(stent placement first, followed by laparoscopic one-stage anastomosis) and the control group(conventional emergency laparotomy), 49 cases each group. The stoma rate, intraoperative condition, postoperative condition, complications and 5-year survival rate were compared between the two groups. Results Compared with the control group, the stent group had lower stoma rate(4.0% vs. 91.8%), shorter operation time(P<0.001), smaller incision(P<0.001), less bleeding(P<0.001), more lymph node dissection(P=0.020), shorter postoperative exhaust time(P=0.024), earlier fluid intake time(P=0.009), shorter painkiller use time(P<0.001), shorter postoperative hospital stay(P<0.001), fewer complications of stoma(P=0.027) and fewer complications of wound infection(P=0.031). The tumor size(P=0.398), hospitalization cost(P=0.498), postoperative bleeding(P=0.495), anastomotic leakage(P=0.320), intestinal obstruction(P=0.204) and 5-year survival rate(P=0.527) were similar in the two groups. Conclusion Stent combined with laparoscopic treatment of colorectal cancer patients with obstruction has obvious short-term efficacy, similar long-term efficacy, and does not increase the risk of tumor spread and metastasis. It is recommended for the treatment of obstructive colorectal cancer.