Abstract: Objective To explore the effect of transverse abdominal plane(TAP) block combined with parecoxib sodium preemptive analgesia on postoperative pain, inflammatory factors and recovery in patients with colon cancer. Methods Seventy-two patients with colon cancer admitted to our hospital from September 2018 to September 2019 were divided into TAP group and combination group according to the method of random number table, 36 cases in each group. Two groups were treated with TAP block and TAP block combined with parecoxib sodium for preemptive analgesia respectively. The degree of postoperative pain, inflammatory factor level and postoperative recovery were compared between the two groups. Results The VAS score of the combined group was lower than that of TAP group(P<0.05). The VAS score of the two groups decreased gradually(P<0.05). There was interaction effect between groups and time points. The levels of TNF-α, IL-6, IL-10 [(19.3±3.1) ng/L,(18.8±3.3) ng/L,(171.3±13.0) ng/L] of the combined group were lower than that of the TAP group [(23.6±4.0) ng/L,(21.7±3.6) ng/L,(185.5±14.3) ng/L], there was statistically significant difference(t=5.098, 3.563, 4.408, all P<0.001). The postoperative bed time, first exhaust time, hospitalization time [(31.8±12.4) h,(41.2±11.9) h,(17.0±2.6) d] of the combined group were shorter than the TAP group [(40.1±13.2) h,(49.6±13.6) h,(19.6±3.1) d, t=2.750, 2.789, 3.856, all P<0.05]. Conclusion The application of TAP block combined with parecoxib sodium preemptive analgesia in the anesthesia of patients undergoing colorectal cancer surgery has significant effect. It can significantly reduce postoperative pain, reduce the level of inflammatory factors, and promote the early recovery of patients after surgery, which is worthy of clinical implementation.