Abstract: Objective To explore the therapeutic effect of Danggui Shaoyao powder on pelvic inflammation and its influence on fibrinogen, hematocrit, ESR and inflammatory factors of patients. Methods A total of 96 patients with pelvic inflammatory disease admitted to our hospital from December 2008 to December 2018 were randomly divided into two groups according to the digital table method. The control group was treated with metronidazole, and the observation group was treated with Danggui Shaoyao Powder. The fibrinogen, hematocrit and erythrocyte sedimentation rate of patients were measured by automatic biochemical analyzer. The levels of interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), and C-reactive protein(CRP) were detected by enzyme-linked immunosorbent assay. The total effective rate, hemodynamics, and inflammatory factor levels in the two groups were compared. Results The clinical effective rate of the observation group(97.9%) was higher than that of the control group(72.9%, χ²=12.042, P=0.001). After treatment, the fibrinogen(2.5±0.1) g/L, hematocrit(34.9±1.3)% and erythrocyte sedimentation rate(11.9±1.7) mm in the observation group were all lower than those in the control group[(3.1±0.1) g/L,(40.2±1.3)%,(24.2±1.1) mm, t=33.516, 19.825, 41.714, all P<0.001]. Meanwhile, the levels of IL-6(59.2±4.9) ng/mL, CRP(5.1±1.2) ng/mL and TNF-α(3.2±1.2) mg/mL in the observation group were all lower than those in the control group [(88.5±4.9) ng/mL,(8.6±0.8) ng/mL,(7.1±1.0) mg/mL, t=36.460, 24.115, 23.169, all P<0.001]. Conclusion The treatment of pelvic inflammatory disease with Danggui Shaoyao powder can effectively improve the inflammatory factors such as IL-6, CRP and TNF-α, and promote the hemorheological indexes such as fibrinogen, hematocrit and erythrocyte sedimentation rate. It improves the therapeutic effect, which is worth popularizing.