Abstract: Objective To explore the effects of cognitive behavioral therapy for insomnia on sleep quality, depression and anxiety in patients with alcohol-induced mental and behavioral disorders. Methods A total of 66 patients with alcohol-induced mental and behavioral disorders who met the inclusion criteria were enrolled from May 2017 to December 2018, and randomized into observation group(33 patients) and control group(33 patients). Patients in the control group received routine treatment and nursing intervention. On this basis, the observation group further accepted cognitive behavioral therapy intervention for insomnia. The total intervention time lasted for 4 weeks. The time of sleep onset, total sleep time, sleep efficiency, sleep quality, depression and anxiety of the two groups were measured before and after treatment. Results There were no significant differences in demographic data and baseline Pittsburgh Sleep Quality Index scores, depression self-rating scale scores and anxiety self-rating scale scores between the two groups(P>0.05). After 4 weeks of intervention, the observation group's time of sleep onset(1.77±0.52 vs. 2.21±0.67, P=0.004), total sleep time(1.26±0.83 vs. 1.72±0.95, P=0.040), sleep efficiency(0.76±0.84 vs. 1.26±0.75, P=0.013), Pittsburgh Sleep Quality Index questionnaire score(observation 9.38±6.29 vs. 13.54±6.85, P=0.013), depression self-rating scale score(36.81±7.76 vs. 45.47±8.25, P<0.001), and anxiety self-rating scale score(33.18±6.73 vs. 42.26±11.48, P<0.001) were significant lower than those of the control group(all P<0.05). Conclusion Cognitive behavioral therapy for insomnia can effectively improve the quality of sleep, depression and anxiety in patients with mental and behavioral disorders caused by alcohol, reduce the sleep time of patients alcohol-induced mental and behavioral disorders, increase their total sleep time, improve their sleep efficiency, improve sleep quality, and help patients recover from their illness.